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A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
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  11. Association Of Arterial Stiffness Indices With Framingham Cardiovascular Disease Risk Score

Association of Arterial Stiffness Indices with Framingham Cardiovascular Disease Risk Score

Lin Jin1,2, LanYue Tong3, CuiQin Shen3

  • 1Department of Ultrasound, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, 201800 Shanghai, China.

Reviews in Cardiovascular Medicine
|July 30, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Arterial stiffness indices, arterial velocity pulse index (AVI) and arterial pressure volume index (API), show U-shaped links with cardiovascular disease risk. These findings may guide early interventions for preventing heart disease.

Area of Science:

  • Cardiovascular Physiology
  • Biomarkers of Cardiovascular Risk

Background:

  • Arterial stiffness indices, including arterial velocity pulse index (AVI) and arterial pressure volume index (API), are recognized indicators of cardiovascular disease (CVD) risk.
  • Understanding the precise relationship between these non-invasive markers and CVD risk is crucial for early detection and prevention strategies.

Purpose of the Study:

  • To investigate the dose-response associations between arterial velocity pulse index (AVI) and arterial pressure volume index (API) and the Framingham cardiovascular disease risk score (FCVRS).
  • To explore the non-linear relationships between key arterial stiffness indices and overall cardiovascular disease risk.

Main Methods:

  • Analysis of data from a cohort of individuals aged 18 years and older with recorded arterial stiffness indices.
  • Utilized Pearson's correlation coefficients and multivariate linear analyses to assess associations.
Keywords:
Framingham scorearterial pressure volume indexarterial stiffnessarterial velocity pulse index

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  • Employed restricted cubic spline regression to model the non-linear "dose-response" relationships between AVI, API, and FCVRS.

    • Main Results:

    • Significant U-shaped associations were observed between both AVI and API with FCVRS in restricted cubic spline models.
    • The lowest cardiovascular disease risk scores were associated with AVI around 8 units and API around 18 units.
    • Elevated FCVRS showed rapid increases after AVI surpassed 12 units (peaking around 27 units) and API surpassed 23 units (flattening after 52 units).

    Conclusions:

    • Arterial velocity pulse index (AVI) and arterial pressure volume index (API) exhibit U-shaped associations with the Framingham cardiovascular disease risk score (FCVRS).
    • These findings offer novel insights into the complex relationship between arterial stiffness and cardiovascular risk.
    • The identified associations may inform targeted early treatment and lifestyle modification strategies for cardiovascular disease prevention.