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The Role of Lipid Subcomponents in the Development of Atherosclerotic Plaques

Lei Nie1, Xuying Xiang1, Cheng Wen1

  • 1Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

Atherosclerosis involves lipid changes. This review explores how cholesteryl ester (CE), cholesterol, triacylglycerol (TG), and phospholipid (PL) contribute to the disease, offering new prevention and treatment insights.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Pathophysiology

Background:

  • Atherosclerosis (AS) is a chronic cardiovascular and cerebrovascular disease.
  • AS pathogenesis is linked to lipid abnormalities, including cholesterol, triacylglycerol, and phospholipid metabolism.

Purpose of the Study:

  • To review the roles of different lipid subcomponents in AS development.
  • To elucidate the mechanisms underlying lipid involvement in AS.
  • To propose novel strategies for AS prevention, diagnosis, and treatment.

Main Methods:

  • Literature review of studies on lipid metabolism and atherosclerosis.
  • Analysis of the pathophysiological roles of cholesteryl ester (CE), cholesterol, triacylglycerol (TG), and phospholipid (PL).

Main Results:

  • Specific lipid subcomponents play distinct roles in AS progression.
  • Mechanisms involve lipid accumulation, inflammation, and endothelial dysfunction.

Conclusions:

  • Understanding lipid subcomponent roles is crucial for AS management.
  • Targeting specific lipid pathways may offer new therapeutic avenues for atherosclerosis.

Keywords:
atherosclerosis plaquelipid metabolismlipid subcomponents

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