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The Prognostic Role of Programmed Ventricular Stimulation in the Risk Stratification of Sudden Cardiac Death

Michele Iavarone1, Anna Rago1, Riccardo Molinari1

  • 1Cardiology Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", AORN Ospedali dei Colli Monaldi Hospital, 80131 Naples, Italy.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

Sudden cardiac death (SCD) prevention relies on identifying high-risk patients for implantable cardioverter-defibrillators (ICDs). Programmed ventricular stimulation (PVS) is evaluated for its role in SCD risk stratification across various clinical scenarios.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Preventive Medicine

Background:

  • Sudden cardiac death (SCD) is a major cause of mortality.
  • Accurate risk stratification is crucial for primary prevention with implantable cardioverter-defibrillators (ICDs).
  • Non-invasive risk indexes have limitations in stratifying SCD risk in asymptomatic cardiac patients.

Purpose of the Study:

  • To review the utility of programmed ventricular stimulation (PVS) for SCD risk stratification.
  • To assess PVS performance in diverse clinical settings.
  • To provide a comprehensive overview of PVS in SCD prevention strategies.

Main Methods:

  • Systematic review of existing literature on PVS for SCD risk stratification.
  • Analysis of data from studies involving patients with acquired or inherited cardiac diseases.
  • Evaluation of PVS efficacy in identifying patients who may benefit from ICD implantation.

Main Results:

  • PVS has been historically used and is guideline-recommended for SCD risk stratification.
  • The effectiveness of PVS in asymptomatic patients with cardiac disease requires further investigation.
  • Data synthesis will clarify PVS's role in different clinical contexts.

Conclusions:

  • Programmed ventricular stimulation (PVS) remains a key tool for sudden cardiac death (SCD) risk stratification.
  • Further research is needed to optimize PVS use in asymptomatic patient populations.
  • PVS plays a significant role in guiding implantable cardioverter-defibrillator (ICD) therapy decisions.

Keywords:
programmed ventricular stimulationrisk stratificationsudden cardiac death

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