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Progress and Challenges of Understanding Cardiorenal Syndrome Type 3

Raquel Silva Neres-Santos1, Giovana Marchini Armentano1, Jéssica Verônica da Silva1

  • 1Laboratory of Cardiovascular Immunology, Center of Natural and Human Sciences (CCNH), Federal University of ABC, 09210-170 Santo André, SP, Brazil.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

Researchers are exploring cardiorenal syndromes (CRSs) using advanced "omics" technologies. This review focuses on micro-RNAs, epigenetic factors, and extracellular vesicles in understanding CRS type 3.

Area of Science:

  • Cardiovascular and Renal Medicine
  • Molecular Biology
  • Biotechnology

Background:

  • Cardiorenal syndromes (CRSs) involve complex interactions between kidney and heart pathologies.
  • Recent advancements in "omics" technologies offer new insights into CRS mechanisms.
  • Understanding the kidney-heart axis is crucial for developing effective treatments.

Purpose of the Study:

  • To review current knowledge on cardiorenal syndromes (CRSs).
  • To highlight the role of "omics" technologies in understanding CRSs.
  • To focus on future perspectives for CRS type 3.

Main Methods:

  • Literature review of cardiorenal syndromes.
  • Analysis of "omics" data, including micro-RNAs (miRNAs), epigenetics, and extracellular vesicles (EVs).
  • Focus on large-scale analysis techniques for data integration.

Main Results:

  • Micro-RNAs (miRNAs), epigenetic factors, and extracellular vesicles (EVs) are key players in CRSs.
  • "Omics" approaches are revolutionizing the understanding of the kidney-heart axis.
  • Integration of large-scale data is essential for advancing CRS research.

Conclusions:

  • Future research should leverage "omics" to unravel CRS pathophysiology.
  • Targeting miRNAs, epigenetic factors, and EVs holds therapeutic potential for CRSs.
  • Further investigation into CRS type 3 is warranted.

Keywords:
acute cardiac injuryacute kidney injuryacute renocardiac syndromecardiorenal syndrome type 3epigeneticsheart failure

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