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Neglected Tropical Diseases and Sudden Cardiac Death: The NET-Heart Project

Andrés F Miranda-Arboleda1,2, Luis Gerardo González-Barrera3, Kiera Liblik4

  • 1Division of Cardiology, Kingston Health Science Centre, Queen's University, Kingston, ON K7L 2V7, Canada.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

Sudden cardiac death (SCD) is a significant cause of mortality, with neglected tropical diseases (NTDs) increasingly recognized as contributing factors. This review explores the link between specific NTDs and fatal arrhythmias, highlighting underrecognized cardiac risks.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Sudden cardiac death (SCD) accounts for substantial global mortality, traditionally linked to known cardiovascular diseases.
  • Despite advancements in cardiovascular care, SCD rates have not proportionally decreased, suggesting overlooked causes.
  • Neglected tropical diseases (NTDs), prevalent in marginalized populations, are emerging as significant contributors to cardiovascular mortality.

Purpose of the Study:

  • To review the association between selected neglected tropical diseases (NTDs) and sudden cardiac death (SCD).
  • To highlight underrecognized cardiac pathologies contributing to fatal arrhythmias.
  • To discuss the impact of NTD therapies on cardiac complication risks.

Main Methods:

  • Literature review of studies examining the relationship between NTDs and cardiovascular complications.
  • Analysis of emerging evidence on NTDs causing fatal arrhythmias.
  • Synthesis of data on cardiac risks associated with specific NTD treatments.

Main Results:

  • The link between Chagas disease and SCD is well-established.
  • Emerging research indicates other NTDs with cardiovascular involvement can precipitate fatal arrhythmias.
  • Certain NTD treatments increase the risk of malignant arrhythmias and other cardiac issues.

Conclusions:

  • NTDs represent an underrecognized cause of sudden cardiac death.
  • Further research is needed to understand and mitigate cardiac risks associated with NTDs.
  • Addressing NTDs is crucial for reducing the global burden of cardiovascular mortality.

Keywords:
myocarditisneglected tropical diseasessudden cardiac deathventricular arrhythmias

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