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Hypertensive Heart Disease: Mechanisms, Diagnosis and Treatment

Xuewei Huang1, Lizhi Hu2, Zhuojun Long2

  • 1Department of Cardiology, The Third Xiangya Hospital, Central South University, 410013 Changsha, Hunan, China.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

Hypertensive heart disease (HHD) involves complex mechanisms like inflammation and metabolic changes. Understanding these is key to developing new treatments and improving patient outcomes globally.

Area of Science:

  • Cardiology
  • Pathophysiology
  • Public Health

Background:

  • Hypertensive heart disease (HHD) is a major global health concern, ranging from mild functional changes to severe heart failure.
  • Understanding the progression of HHD is crucial for effective management and treatment strategies.

Purpose of the Study:

  • To provide a comprehensive review of the pathophysiological mechanisms underlying HHD.
  • To highlight current diagnostic tools and therapeutic interventions for HHD.
  • To underscore the global significance of HHD and enhance understanding for improved public health.

Main Methods:

  • Literature review focusing on pathophysiological mechanisms of HHD.
  • Analysis of neurohormonal activation, inflammation, and metabolic remodeling in HHD.
  • Overview of current diagnostic imaging and treatment modalities for HHD.

Main Results:

  • Neurohormonal activation, inflammation, and metabolic remodeling are key drivers of HHD.
  • Advanced imaging techniques allow for precise assessment of HHD severity.
  • Pharmacologic, lifestyle, and device-based interventions show potential for HHD management.

Conclusions:

  • A deeper understanding of HHD pathophysiology is essential for developing targeted therapies.
  • Integrated approaches combining diagnostics and treatments are vital for managing HHD globally.
  • Continued research and awareness are necessary to mitigate the public health impact of HHD.

Keywords:
diagnosishypertensive heart diseasemechanismstreatment

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