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Relation between Systemic Inflammatory Index (SII) and Hair Trace Elements, Metals and Metalloids Concentration in
Tomasz Urbanowicz1, Anetta Hanć1, Anna Olasińska-Wiśniewska1
1Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Insights
Trace elements like lithium, antimony, chromium, and iron in scalp hair correlate with inflammation markers in coronary artery disease (CAD) patients. This study highlights iron
Area of Science:
- Cardiovascular Medicine
- Trace Element Analysis
- Biochemistry
Background:
- Coronary artery disease (CAD) development involves generic, clinical, lifestyle factors, and inflammation.
- Investigating trace element concentrations offers insights into pathological processes of CAD.
Purpose of the Study:
- To explore the relationship between scalp hair trace element concentrations and inflammatory markers in patients with coronary artery disease (CAD).
- To determine if specific trace elements correlate with systemic inflammation in individuals experiencing anginal symptoms.
Main Methods:
- Prospective analysis of 35 patients (22 males, 13 females; median age 67 years) with anginal symptoms.
- Patients were categorized into epicardial coronary artery disease (CAD) and non-CAD groups.
- Scalp hair chemical analysis and peripheral blood inflammatory markers were assessed.
Main Results:
- Significant negative correlations were found between hair lithium (Li), antimony (Sb), chromium (Cr), and iron (Fe) concentrations and the systemic inflammatory index (SII) in the CAD group.
- Specifically, a strong correlation was observed between inflammatory activation and iron concentration in CAD patients.
- No similar correlations were identified in the non-CAD group.
Conclusions:
- Scalp hair concentrations of Li, Sb, Cr, and Fe correlate with the systemic inflammatory index (SII) exclusively in patients with coronary artery disease (CAD).
- Iron concentration demonstrates a strong association with inflammatory activation in individuals with CAD.
Background:
Coronary artery atherosclerosis development and progression are related to generic, clinical, and lifestyle factors combined with inflammatory activation. The relationship between trace element concentration and morbidity is under investigation to gain a clearer understanding of underlying pathological processes.
Methods:
Thirty-five consecutive patients (22 males and 13 females) with a median [interquartile range (IQR)] age of 67 (61-73) years presenting with anginal symptoms were included in the single center prospective analysis in 2022 and divided into a epicardial coronary artery disease (CAD) and non-CAD group. Scalp hair chemical analysis and inflammatory markers from a peripheral blood count were analyzed.
Results:
The correlation analysis of elements and inflammatory indexes showed statistical significance between median hair lithium (Li) concentration and the systemic inflammatory index (SII) (r = -0.476, p = 0.046), antimony (Sb) (r = -0.521, p = 0.028) followed by chromium (Cr) (r = -0.478, p = 0.045) and iron (Fe) (r = -0.604, p = 0.008) in the CAD group. Similar correlations were not found in non-CAD group.
Conclusions:
The correlation between scalp hair lithium (Li), antimony (Sb), chromium (Cr) and iron (Fe) concentration and the systemic inflammatory index (SII) were revealed only in patients with coronary artery disease. Our analysis identified a strong correlation between inflammatory activation and iron concentration.
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