Improving Transition of Care for Pediatric Patients With Chronic Kidney Disease: A Pilot Project

Melvin Chan1, Sarah Young2, Melisha Hanna1

  • 1Pediatric Nephrology, Children's Hospital Colorado, Aurora, USA.

Cureus
|July 30, 2024
PubMed

Insights

Younger age and male gender predict poor transition readiness in pediatric chronic kidney disease (CKD) patients. A structured remote curriculum significantly improved transition readiness across all domains.

Area of Science:

  • Pediatric Nephrology
  • Transition of Care
  • Chronic Kidney Disease Management

Background:

  • Transitioning pediatric patients to adult care is crucial for long-term health outcomes.
  • Poor transition from pediatric to adult healthcare systems is associated with increased healthcare utilization and worse kidney outcomes.
  • Limited research exists on predictors of transition readiness and effective interventions for pediatric patients with chronic kidney disease (CKD).

Purpose of the Study:

  • To identify predictors of transition readiness in adolescents and young adults with CKD.
  • To evaluate the effectiveness of a structured, remote curriculum in improving transition readiness.
  • To assess the impact of age and gender on transition readiness in this population.

Main Methods:

  • Enrolled 42 non-dialysis, non-transplant CKD patients (stage 2+, aged 14+).
  • Collected demographic and clinical data, assessing transition readiness using the Transition Readiness Assessment Questionnaire (TRAQ).
  • Implemented a structured, remote curriculum and administered repeat TRAQ assessments after six months.

Main Results:

  • Younger age and male gender were identified as risk factors for poor transition readiness.
  • Older age positively correlated with higher TRAQ scores in medication, appointment, and total domains.
  • Male gender was associated with lower TRAQ scores in appointment and communication domains.
  • The curriculum improved TRAQ scores by approximately 25% across all domains within six months.
  • Follow-up interval (3 vs. 6 months) did not significantly impact outcomes.

Conclusions:

  • Younger age and male gender are significant risk factors for inadequate transition readiness in pediatric CKD.
  • A structured, remote educational curriculum effectively enhances transition readiness in this patient group.
  • These findings highlight the need for targeted interventions to support vulnerable patient subgroups during care transitions.

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
69
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
77
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
286
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
115
Renal Drug Excretion: Tubular Secretion01:28

Renal Drug Excretion: Tubular Secretion

Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
160
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.3K