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Related Experiment Video

Updated: Jun 18, 2025

Murine Fecal Isolation and Microbiota Transplantation
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Gut Microbiome and Atherosclerosis: A Mendelian Randomization Study.

Yue Li1, Yunxian Chen1, Zhe Li2

  • 1Department of Cardiology, Yue Bei People's Hospital, Shantou University Medical College, 512099 Shaoguan, Guangdong, China.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed
Summary

The gut bacterium Firmicutes is causally linked to a lower risk of coronary atherosclerosis. This finding may offer new therapeutic targets for atherosclerosis by focusing on gut microbiota interventions.

Keywords:
cerebral atherosclerosiscoronary atherosclerosisintestinal microbiotaphylum Firmicutes

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Area of Science:

  • Genetics
  • Microbiology
  • Cardiovascular Disease

Background:

  • Atherosclerosis is increasingly linked to the gut microbiota, but causal relationships and specific taxa remain unclear.
  • Existing studies show variability in gut microbiota composition, hindering definitive conclusions.
  • Identifying key gut microbiota taxa (GM taxa) is crucial for understanding their role in atherosclerosis.

Purpose of the Study:

  • To identify specific gut microbiota taxa at various taxonomic levels (phylum to genus) associated with atherosclerosis.
  • To investigate potential causal links between gut microbiota and atherosclerosis using advanced statistical methods.

Main Methods:

  • A two-sample Mendelian randomization (MR) analysis was performed using summary data from the MiBioGen consortium (gut microbiota) and the FinnGen Consortium (atherosclerosis).
  • The primary analytical method was the inverse variance-weighted (IVW) method, supplemented by weighted median, MR-Egger, and other MR techniques.
  • Sensitivity analyses included Cochrane's Q-test, MR-Egger intercept, MR-PRESSO, and leave-one-out analyses to ensure robustness.

Main Results:

  • The MR study analyzed 211 gut microbiota taxa for their risk association with atherosclerosis.
  • Twenty nominal links and one significant causal link were identified.
  • The phylum Firmicutes showed a significant causal association with reduced coronary atherosclerosis (OR = 0.852, p = 0.004), persisting after Bonferroni correction.

Conclusions:

  • The phylum Firmicutes causally influences the reduced incidence of coronary atherosclerosis.
  • These findings suggest that targeting gut microbiota, specifically Firmicutes, could represent a novel therapeutic strategy for atherosclerosis.