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The Association between Left Ventricular End-Diastolic Diameter and Long-Term Mortality in Patients with Coronary

Qiang Li1,2, Haozhang Huang1,2, Xiaozhao Lu1,2

  • 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, China.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

Enlarged left ventricular end-diastolic diameter (LVEDD) is an independent predictor of all-cause mortality in coronary artery disease (CAD) patients. LVEDD measurement aids in risk stratification and identifying therapeutic targets for CAD management.

Area of Science:

  • Cardiology
  • Echocardiography
  • Morbidity and Mortality Studies

Background:

  • Left ventricular end-diastolic diameter (LVEDD) is a standard echocardiographic measure.
  • Increased LVEDD often correlates with left ventricular (LV) dysfunction.
  • The prognostic value of LVEDD for all-cause mortality in coronary artery disease (CAD) patients remains unclear.

Purpose of the Study:

  • To investigate the association between LVEDD and all-cause mortality in a large cohort of patients with CAD.
  • To determine if LVEDD can serve as an independent predictor of mortality in this population.

Main Methods:

  • Retrospective analysis of 33,147 CAD patients from the Cardiorenal Improvement study (NCT04407936).
  • Patients were stratified into quartiles based on LVEDD measurements.
  • Kaplan-Meier analysis, log-rank tests, restricted cubic splines, and Cox proportional hazards models were employed to assess mortality risk.

Main Results:

  • A total of 33,147 patients (mean age 63.0 ± 10.6 years, 24.0% female) were analyzed.
  • During a mean follow-up of 5.2 years, 4,288 deaths occurred.
  • Patients in the highest LVEDD quartile (Quartile 4) exhibited significantly higher mortality (18.05%) compared to lower quartiles (Quartile 1-3, 11.15%, p < 0.001).
  • Adjusted analysis revealed a 1.19-fold increased risk of all-cause mortality for the highest LVEDD quartile (95% CI: 1.09-1.30).

Conclusions:

  • Elevated LVEDD is an independent predictor of all-cause mortality in patients with CAD.
  • LVEDD assessment is valuable for risk stratification in CAD management.
  • LVEDD may guide therapeutic strategies for improving outcomes in CAD patients.
Abstract

Keywords:
coronary artery diseaseleft ventricularleft ventricular end-diastolic diametermortalityprognosis

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