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Remnant Cholesterol to Lymphocyte Ratio as a New Predictor of Prognosis in Patients with Unstable Angina Undergoing

Hui Xi1, Biyang Zhang2, Tienan Sun2

  • 1Peking University International Hospital, 102218 Beijing, China.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

The remnant cholesterol to lymphocyte ratio (RCLR) independently predicts major adverse cardiovascular events (MACE) in unstable angina patients undergoing percutaneous coronary intervention. Higher RCLR indicates increased cardiovascular risk.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Medicine

Background:

  • Remnant cholesterol (RC) and inflammatory cells are implicated in cardiovascular disease (CVD) development.
  • The remnant cholesterol to lymphocyte ratio (RCLR) integrates serum lipid and inflammation levels.
  • RCLR serves as a potential predictive indicator for CVD progression.

Purpose of the Study:

  • To investigate the association between RCLR and major adverse cardiovascular events (MACE).
  • To evaluate RCLR as a predictive marker in patients with unstable angina (UA) undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • RCLR calculated by dividing RC by lymphocyte percentage.
  • 1092 UA patients categorized into four RCLR quartiles.
  • MACE defined as all-cause mortality, non-fatal myocardial infarction, or ischemia-driven revascularization.
  • Multivariable Cox proportional hazard model employed to assess RCLR's independent effect on MACE.

Main Results:

  • MACE incidence significantly increased with higher RCLR quartiles (40.9% in Q4 vs. 9.2% in Q1, p < 0.001).
  • Adjusted analysis confirmed a direct proportionality between RCLR and MACE rates (HR 5.85 for Q4 vs. Q1, p < 0.001).
  • A significant trend of increasing MACE with rising RCLR quartiles was observed (p < 0.001).

Conclusions:

  • RCLR is an independent predictor of MACE in UA patients treated with PCI.
  • The RCLR offers valuable prognostic information for cardiovascular risk stratification.
Abstract

Keywords:
major adverse cardiovascular eventpercutaneous coronary interventionremnant cholesterolremnant cholesterol-lymphocyte ratiounstable angina

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