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Updated: Jun 18, 2025
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Association between Dental and Cardiovascular Diseases: A Systematic Review
Louis Hardan1, Anthony Matta2,3, Rim Bourgi1
1Department of Restorative Dentistry, School of Dentistry, Saint-Joseph University, 1107 2180 Beirut, Lebanon.
Background:
The link between dental, infective and obstructive cardiovascular diseases is debatable.
Aim:
To systematically review the literature to assess the association between dental conditions and development of cardiovascular disease.
Methods:
The systematic review was conducted following the PRISMA guidelines using PubMed (Medline), Web of Science, Scopus, EMBASE and SciELO.
Results:
Out of 6680 records, 82 articles were eligible for inclusion after reviewing titles and abstracts. No association between dental disease and cardiovascular disease has been observed in 10 studies while a potential link has been suggested by the remaining trials. Tooth loss and periodontitis are the main evaluated oral conditions while coronary artery disease, stroke, atherosclerosis and myocardial infarction represent the major cardiovascular events. The interaction between these two clinical entities is based on direct mechanism mediated by systemic inflammatory response, leakage of cytokines and endothelial cells invasion by oral pathogens and indirect mechanism mediated by common risk factors or confounders.
Conclusions:
It seems that tooth loss, periodontitis and poor oral hygiene increase the risk of atherosclerotic cardiovascular events, and subsequently oral health care professionals could contribute to public health cardiovascular control efforts.
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