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Updated: Jun 18, 2025
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Association between Malnutrition and Coronary Plaque Characteristics in Patients with Acute Coronary Syndrome: An
Haihao Yan1, Wenjing Yao2, Qian Yang2
1Department of Internal Medicine, Graduate School of Hebei Medical University, 050017 Shijiazhuang, Hebei, China.
Background:
Malnutrition has a negative impact on patients with arteriosclerotic cardiovascular disease (ASCVD); however, only a few studies have confirmed the effect of malnutrition on atherosclerosis. We aimed to investigate the association between malnutrition and vulnerable plaques via optical coherence tomography (OCT).
Methods:
Overall, 142 acute coronary syndrome (ACS) patients were included in this study. Malnutrition was assessed using the Controlled Nutritional Status Score (CONUT), and plaque vulnerability was measured using OCT. Finally, patients were divided into four groups according to their CONUT scores and body mass index (BMI) 25.0 or not, to further compare the effects of both factors on plaque characteristics in patients.
Results:
OCT results showed that there were significant differences in plaque rupture, thin cap fibroatheroma (TCFA), minimal fiber cap thickness (FCT), thrombus, and macrophage infiltration between different nutritional states [Absent (0-1) vs Mild (2-4) vs Moderate (5-8), plaque rupture: 34.8% vs 52.5% vs 66.7%, p = 0.038; TCFA: 10.1% vs 24.6% vs 33.3%, p = 0.039; minimal FCT: 125.0 vs 110.4 vs 96.9, p = 0.022; thrombus: 50.7% vs 70.5% vs 83.3%, p = 0.019]. Multivariate logistic regression showed that malnutrition was a significant predictor of plaque vulnerability. Plaque rupture: CONUT score (odds ratio [OR]: 1.448, 95% confidence interval [CI]: 1.136-1.845, p = 0.003), Mild (OR: 1.981, 95% CI: 0.932-4.210, p = 0.075), and Moderate (OR: 4.375, 95% CI: 1.048-18.255, p = 0.043); TCFA: CONUT score (OR: 1.334, 95% CI: 1.029-1.730, p = 0.030), Mild (OR: 3.518, 95% CI: 1.251-9.897, p = 0.017), and Moderate (OR: 4.863, 95% CI: 1.019-23.208, p = 0.047); and macrophage: CONUT score (OR: 1.343, 95% CI: 1.060-1.700, p = 0.015), Mild (OR: 3.016, 95% CI: 1.305-6.974, p = 0.010), and Moderate (OR: 4.637, 95% CI: 1.159-18.552, p = 0.030). Combined CONUT score and BMI showed an independent association with macrophages in the malnourished and overweight group (OR: 4.010, 95% CI: 1.188-13.537, p = 0.025).
Conclusions:
Malnutrition is a predictor of vulnerable plaques and is associated with inflammatory progression.
