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Published on: March 7, 2019
Association of Leisure-Time Physical Activity and Mortality Risk in High Cardiovascular Risk Population with and
Huijun Jin1, Xiulin Wang1,2, Hao Dai1
1National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, China.
Higher leisure-time physical activity (LTPA) is linked to reduced mortality. Left ventricular hypertrophy (LVH) did not significantly alter this association in a high cardiovascular risk population, except in females for all-cause mortality.
Area of Science:
- Cardiology
- Public Health
- Exercise Physiology
Background:
- Leisure-time physical activity (LTPA) is associated with reduced mortality risk.
- Increased LTPA may lead to left ventricular hypertrophy (LVH), a condition that could potentially alter its benefits.
- This study investigates the modifying role of LVH on the LTPA-mortality association in a high cardiovascular risk cohort.
Purpose of the Study:
- To determine if left ventricular hypertrophy (LVH) modifies the association between leisure-time physical activity (LTPA) and mortality risk.
- To analyze this relationship within a population at high risk for cardiovascular disease.
- To explore potential sex-specific differences in this interaction.
Main Methods:
- A prospective national cohort of 163,006 participants was analyzed.
- Left ventricular hypertrophy (LVH) was defined using the left ventricular mass/body surface area (LVM/BSA) method.
- Multivariate Cox proportional hazards regression assessed the association between LTPA levels (low, moderate, high) and mortality, adjusting for potential confounders.
Main Results:
- Moderate and high LTPA were associated with reduced cardiovascular and all-cause mortality compared to low LTPA in individuals without LVH.
- In participants with LVH, the association between high or moderate LTPA and reduced cardiovascular mortality persisted.
- The interaction between LVH and LTPA on mortality was not significant overall, but a significant interaction was observed for all-cause mortality in females.
Conclusions:
- Left ventricular hypertrophy (LVH) does not significantly modify the mortality benefits of leisure-time physical activity (LTPA) in a high cardiovascular risk population.
- However, LVH appears to alter the association between LTPA and all-cause mortality specifically in females.
- These findings highlight a potential sex-specific effect of LVH on the protective role of physical activity.
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