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Related Concept Videos

MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

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Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
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Applications Of NMR In Biology01:25

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Updated: Jun 18, 2025

Concentration of Metabolites from Low-density Planktonic Communities for Environmental Metabolomics using Nuclear Magnetic Resonance Spectroscopy
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Bacterial metabolomics: current applications for human welfare and future aspects.

Qazi Mohammad Sajid Jamal1, Varish Ahmad2

  • 1Department of Health Informatics, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.

Journal of Asian Natural Products Research
|July 30, 2024
PubMed
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An imbalanced microbiome is linked to diseases. This review explores bacterial metabolites, their production, and their importance for human health, utilizing statistical and machine learning analyses for novel applications.

Keywords:
biodegradationdiseasehuman healthmetabolitesmicrobial metabolomicssensing

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Area of Science:

  • Microbiology
  • Metabolomics
  • Bioinformatics

Background:

  • Gut microbiome imbalance is associated with diseases like cancer, inflammatory bowel disease, obesity, and neurological disorders.
  • Bacteria and their by-products have diverse industrial and clinical applications.

Purpose of the Study:

  • To review metabolite production strategies and methodologies for bacterial metabolites.
  • To highlight the importance of bacterial metabolites for human well-being.
  • To explore the application of statistical and machine learning analyses in separating bacterial metabolites.

Main Methods:

  • Literature review focusing on metabolome research and host-gut microbiota interactions.
  • Analysis of statistical and machine learning approaches for metabolite separation.
  • Discussion of metabolite production strategies and their biological impacts.

Main Results:

  • Metabolome research has established the biological impacts of metabolites on host and gut microbiota interactions.
  • Statistical and machine learning analyses offer new opportunities for bacterial metabolite applications.
  • Bacterial metabolites play a crucial role in human health and disease.

Conclusions:

  • Understanding bacterial metabolite production and function is vital for human well-being.
  • Advanced analytical methods can unlock new applications for bacteria and their metabolites in environmental and medical sciences.
  • Targeting the microbiome through its metabolites presents therapeutic potential for various diseases.