Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

913
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
913
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

521
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
521
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

1.2K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thiazide diuretics and primary hyperparathyroidism.

British journal of hospital medicine (London, England : 2005)·2023
Same author

Encephalitis as an initial presentation of type 2 amiodarone-induced thyrotoxicosis.

BMJ case reports·2023
Same author

A retroperitoneal ectopic adrenocortical carcinoma in a patient with Cushing's syndrome.

British journal of hospital medicine (London, England : 2005)·2023
Same author

Epidemiology of craniopharyngiomas: a population-based study in Malta.

Endocrine oncology (Bristol, England)·2023
Same author

The foot in diabetes - a reminder of an ever-present risk.

Clinical medicine (London, England)·2023
Same author

Management of lithium-associated hyperparathyroidism with cinacalcet hydrochloride.

British journal of hospital medicine (London, England : 2005)·2023

Related Experiment Video

Updated: Jun 18, 2025

Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

16.2K

Not all ketosis is type 1 - remember Flatbush.

Sarah Craus1,2, Abigail Mula1,2, David Coppini2,3,4

  • 1Department of Medicine, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.

British Journal of Hospital Medicine (London, England : 2005)
|July 30, 2024
PubMed
Summary
This summary is machine-generated.

A 35-year-old man presented with symptoms of uncontrolled diabetes, including excessive thirst and urination, and significant weight loss. His high HbA1c and blood glucose confirmed new-onset Type 2 Diabetes Mellitus (T2DM).

Keywords:
Atypical diabetesAutoantibodiesDiabetic ketoacidosisKetosis-prone diabetes

More Related Videos

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

9.4K
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

68.2K

Related Experiment Videos

Last Updated: Jun 18, 2025

Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

16.2K
Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

9.4K
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

68.2K

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Clinical Case Study

Background:

  • Type 2 Diabetes Mellitus (T2DM) is a growing global health concern.
  • Early diagnosis and management are crucial for preventing complications.

Purpose of the Study:

  • To present a case of new-onset T2DM in a young adult.
  • To highlight the clinical presentation and initial diagnostic findings.

Main Methods:

  • Case report of a 35-year-old male patient.
  • Clinical examination, including assessment of polyuria and polydipsia.
  • Laboratory investigations: HbA1c, blood glucose, ketone levels, urinalysis, and metabolic panel.

Main Results:

  • Patient presented with severe hyperglycemia (HbA1c 119 mmol/mol, blood glucose 22.84 mmol/L).
  • Symptoms included polyuria, polydipsia, and 5kg weight loss.
  • Positive ketones and glycosuria noted, with mild metabolic acidosis.

Conclusions:

  • This case underscores the importance of considering T2DM in young adults presenting with classic hyperglycemic symptoms.
  • Prompt diagnosis and intervention are vital for managing T2DM and its acute complications.