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IMPROVEMENT OF TAMOXIFEN INDUCED FOVEAL CAVITATION WITH TOPICAL DORZOLAMIDE THERAPY
Khalil Ghasemi Falavarjani1, David Sarraf2,3
1Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Retinal Cases & Brief Reports
|July 30, 2024
Summary
Tamoxifen toxicity can cause severe vision problems like macular holes. This case shows that stopping tamoxifen and using eye drops (dorzolamide) can significantly improve vision and heal these eye conditions.
Area of Science:
- Ophthalmology
- Toxicology
Background:
- Tamoxifen is a widely used medication for breast cancer treatment.
- Tamoxifen retinopathy is a known side effect, characterized by visual disturbances and retinal changes.
- Foveal cavitation and macular holes are severe manifestations of tamoxifen toxicity.
Purpose of the Study:
- To report a case of severe foveal cavitation and macular hole caused by tamoxifen.
- To evaluate the efficacy of tamoxifen cessation and topical dorzolamide therapy in managing this condition.
Main Methods:
- A 45-year-old female patient with bilateral tamoxifen maculopathy was assessed.
- Optical coherence tomography (OCT) revealed bilateral foveal cavitation, more pronounced in the right eye (OD), with internal limiting membrane draping.
- Treatment involved discontinuing tamoxifen and initiating topical dorzolamide drops.
Main Results:
- Significant improvement in foveal cavitation was observed in the right eye (OD) after treatment.
- Near resolution of the macular hole was achieved.
- No recurrence of symptoms was noted 4 months after discontinuing topical drops.
Conclusions:
- Topical dorzolamide therapy, combined with tamoxifen cessation, appears to be a beneficial treatment for severe foveal cavitation and macular holes secondary to tamoxifen toxicity.
- This approach offers a potential strategy for managing vision-threatening side effects of tamoxifen therapy.
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