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Glycemic control and study of lipid and bone metabolism in type 1 diabetic children

Pilar Calmarza1, Rasha Isabel Pérez-Ajami2, Carlos Prieto-López3

  • 1Servicio de Bioquímica Clínica, Hospital Universitario Miguel Servet, Zaragoza, España; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, Zaragoza, España; Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, España.

Biomedica : Revista Del Instituto Nacional De Salud
|July 30, 2024
PubMed

Insights

Children with type 1 diabetes show poorer metabolic control during puberty. Bone formation markers correlate inversely with disease duration and glycated hemoglobin levels, highlighting the importance of metabolic control for bone health.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Bone Metabolism

Context:

  • Type 1 diabetes mellitus (T1DM) is a prevalent chronic childhood condition.
  • T1DM poses risks for early cardiovascular disease and impacts bone health.
  • Understanding T1DM's effects on pediatric bone health is crucial.

Purpose:

  • To characterize demographic and biochemical profiles of pediatric T1DM patients.
  • To evaluate metabolic, lipid, and bone parameters in children with T1DM.
  • To investigate correlations between disease parameters and bone health markers.

Summary:

  • A retrospective study analyzed 124 pediatric T1DM patients from a Spanish tertiary hospital.
  • Results indicated poorer metabolic control during puberty but acceptable lipid profiles.
  • Bone formation markers showed an inverse correlation with disease duration and metabolic control (HbA1c).

Impact:

  • Bone health in pediatric T1DM is linked to disease duration and metabolic control.
  • Achieving optimal metabolic control positively influences lipid and bone profiles.
  • Findings emphasize proactive bone health monitoring in children with T1DM.

Keywords:
Diabetes mellitustype 1glycated hemoglobinlipidsosteocalcinchildren

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