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Corrigendum to 'Targeting multidrug-resistant <i>Candida</i>: Cu<sub>x</sub>Te nanoflowers synergis-tically facilitate fungal clearance via cuproptosis death and host immune activation' [Mater. Today Bio, 37 (April 2026) 102857].

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Updated: Jun 18, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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The complex interplay between ferroptosis and atherosclerosis.

Mao Zhang1, Jiangping Li2, Wei Hu1

  • 1Department of Vascular Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 30, 2024
PubMed
Summary
This summary is machine-generated.

Ferroptosis, an iron-dependent cell death, is a key factor in atherosclerosis development. Targeting ferroptosis pathways may offer novel treatments for this cardiovascular disease.

Keywords:
AtherosclerosisFerroptosisInflammationLipid peroxidationOxidative stress

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Area of Science:

  • Cardiovascular Science
  • Cellular Biology
  • Pathology

Background:

  • Atherosclerosis involves arterial plaque buildup, a major cause of cardiovascular disease.
  • Ferroptosis, a regulated cell death process dependent on iron, is increasingly recognized in disease pathology.
  • Understanding ferroptosis's role in atherosclerosis is crucial for developing new therapeutic strategies.

Purpose of the Study:

  • To review the current understanding of ferroptosis in atherosclerosis.
  • To explore the molecular mechanisms linking lipid peroxidation and iron metabolism to plaque formation.
  • To evaluate ferroptosis as a potential therapeutic target for atherosclerosis.

Main Methods:

  • Literature review of recent studies on ferroptosis and atherosclerosis.
  • Analysis of molecular pathways involved in lipid peroxidation and iron metabolism.
  • Evaluation of existing and potential therapeutic interventions targeting ferroptosis.

Main Results:

  • Ferroptosis contributes significantly to the development and progression of atherosclerotic lesions.
  • Dysregulated iron metabolism and lipid peroxidation are central to ferroptosis in atherosclerosis.
  • Targeting ferroptosis pathways shows promise for novel atherosclerosis treatments.

Conclusions:

  • Ferroptosis is a critical mediator in atherosclerosis pathogenesis.
  • Modulating ferroptosis presents a promising avenue for future clinical applications and personalized medicine in cardiovascular disease.
  • Further research is warranted to translate these findings into effective therapies.