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Cutaneous T-cell Lymphoma.

David M Weiner1, Alain H Rook2

  • 1Department of Dermatology, Johns Hopkins University School of Medicine, 601 North Caroline Street, 8th Floor, Baltimore, MD 21287, USA.

Hematology/Oncology Clinics of North America
|July 30, 2024
PubMed
Summary

Cutaneous T-cell lymphoma (CTCL) affects the skin and can spread to other organs. This review covers CTCL

Keywords:
Cutaneous T-cell lymphomaLymphomatoid papulosisMycosis fungoidesPrimary cutaneous anaplastic large cell lymphomaSezary syndrome

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Area of Science:

  • Dermatology and Hematology
  • Oncology
  • Immunopathology

Background:

  • Cutaneous T-cell lymphoma (CTCL) comprises a group of non-Hodgkin lymphomas primarily affecting the skin.
  • CTCL subtypes include mycosis fungoides, Sezary syndrome, lymphomatoid papulosis, and primary cutaneous anaplastic large cell lymphoma.
  • It frequently presents as recalcitrant chronic skin rash, often mimicking other dermatologic and hematologic conditions, leading to diagnostic delays.

Purpose of the Study:

  • To provide a comprehensive introduction to cutaneous T-cell lymphoma.
  • To focus on the clinical presentation, diagnostic approaches, immunopathogenesis, and management strategies for CTCL.

Main Methods:

  • This is a review article, synthesizing existing knowledge on CTCL.
  • Information is gathered from relevant medical literature and clinical expertise.
  • The review focuses on descriptive and analytical summaries of CTCL characteristics.

Main Results:

  • CTCL presents diverse clinical manifestations, often mimicking common skin conditions.
  • Diagnostic delays are common due to the varied presentation and mimicry of other diseases.
  • Understanding the immunopathogenesis is crucial for effective management.

Conclusions:

  • Cutaneous T-cell lymphoma requires careful clinical evaluation and diagnostic workup.
  • Early and accurate diagnosis is essential for optimal patient outcomes.
  • This review provides a foundational understanding for clinicians managing CTCL.