Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

128
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
128
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

3.9K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
3.9K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

69
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
69
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Circulating Glycocalyx Shedding Products As Biomarkers For Evaluating Prognosis Of Patients With Out-of-hospital Cardiac Arrest After Return Of Spontaneous Circulation.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Circulating Glycocalyx Shedding Products As Biomarkers For Evaluating Prognosis Of Patients With Out-of-hospital Cardiac Arrest After Return Of Spontaneous Circulation.

Related Experiment Video

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.3K

Circulating glycocalyx shedding products as biomarkers for evaluating prognosis of patients with out-of-hospital cardiac arrest after return of spontaneous circulation.

Jun Li1, Zhijiang Qi2, Changan Sun3

  • 1Department of Cardiology, Yantai Yuhuangding Hospital, Qingdao University, No. 20 Yudong Road, Yantai City, Shandong Province, China.

Scientific Reports
|July 30, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
GlycocalyxHeparan sulfateHyaluronanNeurological outcome

More Related Videos

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

358
Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
07:18

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

Published on: April 14, 2023

1.7K

Related Experiment Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.3K
Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

358
Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
07:18

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

Published on: April 14, 2023

1.7K

In postcardiac arrest syndrome (PCAS), levels of syndecan-1 (SDC-1), hyaluronan (HA), and heparan sulfate (HS) indicate patient survival and neurological outcomes. These glycocalyx shedding products may serve as important prognostic biomarkers after cardiac arrest.

Area of Science:

  • Cardiovascular Research
  • Biomarkers
  • Endothelial Biology

Background:

  • Endothelial glycocalyx damage is known in postcardiac arrest syndrome (PCAS).
  • The prognostic significance of glycocalyx shedding products in PCAS remains unclear.
  • Key shedding products include syndecan-1 (SDC-1), hyaluronan (HA), and heparan sulfate (HS).

Purpose of the Study:

  • To investigate the expression and prognostic value of SDC-1, HA, and HS in PCAS patients.
  • To correlate glycocalyx shedding with clinical outcomes, including 28-day survival and neurological status.
  • To examine in vitro glycocalyx shedding under simulated ischemic conditions.

Main Methods:

  • Seventy-one out-of-hospital cardiac arrest (OHCA) patients were studied post-return of spontaneous circulation (ROSC).
Out-of-hospital cardiac arrest
Postcardiac arrest syndrome
Syndecan-1
  • SDC-1, HA, and HS levels were measured on days 0, 1, and 3 post-ROSC.
  • In vitro experiments used human umbilical vein endothelial cells (HUVECs) under hypoxia and reoxygenation.

    • Main Results:

    • SDC-1 and HA levels significantly increased within 4 hours of ROSC.
    • Non-survivors showed elevated HA, persistently high SDC-1, and fluctuating HS levels.
    • SDC-1, HA, and HS levels demonstrated prognostic value for 28-day survival, with HS on day 1 predicting neurological outcomes.
    • Elevated SDC-1 and HA correlated with longer no-flow times.

    Conclusions:

    • SDC-1, HA, and HS levels after ROSC may predict 28-day survival in PCAS.
    • Heparan sulfate levels on day 1 are particularly associated with functional neurological outcomes.
    • Glycocalyx shedding products are potential biomarkers for assessing prognosis after cardiac arrest.