Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multistage models of carcinogenesis.

P Armitage

    Environmental Health Perspectives
    |November 1, 1985
    PubMed
    Summary

    The multistage model of carcinogenesis explains cancer incidence across ages and exposures. Evidence suggests both early and late stages are affected by factors like smoking, supporting multi-stage cancer development theories.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Structural intracranial abnormalities and brain volumes in foetuses with congenital heart disease.

    Clinical radiology·2026
    Same author

    Trial analysis by treatment allocated or by treatment received? Origins of 'the intention-to-treat principle' to reduce allocation bias: Part 2.

    Journal of the Royal Society of Medicine·2023
    Same author

    Trial analysis by treatment allocated or by treatment received? Origins of 'the intention-to-treat principle' to reduce allocation bias: Part 1.

    Journal of the Royal Society of Medicine·2023
    Same author

    The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader-Willi Syndromes.

    Journal of autism and developmental disorders·2019
    Same author

    The assessment of fetal brain growth in diabetic pregnancy using in utero magnetic resonance imaging.

    Clinical radiology·2017
    Same author

    Surface reconstructions of foetal brain abnormalities using ultrafast steady state 3D acquisitions.

    Clinical radiology·2014

    Area of Science:

    • Oncology
    • Epidemiology
    • Biostatistics

    Background:

    • The multistage model of carcinogenesis is a widely accepted framework for understanding cancer development.
    • This model helps explain age-incidence power laws and responses to carcinogenic exposures.
    • Previous research has explored two-stage models, particularly for epithelial carcinomas.

    Purpose of the Study:

    • To outline the simple multistage model of carcinogenesis.
    • To evaluate its explanatory power for various cancer phenomena.
    • To discuss its application and implications, including for breast cancer.

    Main Methods:

    • Review and synthesis of the simple multistage model of carcinogenesis.
    • Analysis of existing data on age-incidence power laws.
    • Examination of human population studies on changing carcinogen exposures.
    • Evaluation of animal experiment data with applied carcinogens.
    • Consideration of evidence from smoking cessation studies.
    • Discussion of two-stage models and their application to breast cancer.

    Main Results:

    • The simple multistage model satisfactorily explains the power law of age incidence for many epithelial carcinomas.
    • The model accounts for population responses to changing exposures to carcinogenic agents.
    • It also explains observed effects in animal experiments with applied carcinogens.
    • Evidence from smoking cessation suggests both early and late stages of carcinogenesis are affected.
    • Several two-stage models offer good general explanations for observed phenomena.

    Conclusions:

    • The multistage model of carcinogenesis provides a robust framework for understanding cancer development.
    • The model's flexibility accommodates diverse etiological factors and stages.
    • Further research into specific cellular changes and refined models, like those for breast cancer, is warranted.

    Related Experiment Videos