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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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First Trimester Abortion and Psychiatric Morbidity.

Shreyashi Aryal1, Rachana Sharma Basnet2

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Anxiety and depression are common after early pregnancy loss. While depression lessens over time for both spontaneous and induced abortions, anxiety persists longer after induced abortions compared to spontaneous ones.

Keywords:
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Area of Science:

  • Reproductive Health
  • Mental Health
  • Psychological Morbidity

Background:

  • Early pregnancy loss is a traumatic event associated with psychological distress.
  • Mental illness in this context is linked to obstetric and social factors.
  • Understanding the prevalence and factors influencing mental health post-abortion is crucial.

Purpose of the Study:

  • To determine the prevalence of depression and anxiety before and after first-trimester abortions (spontaneous and induced).
  • To analyze demographic and obstetric factors associated with these psychological morbidities.
  • To assess the temporal changes in anxiety and depression levels post-abortion.

Main Methods:

  • An observational study was conducted over one year.
  • 171 clients experiencing pregnancy loss were enrolled.
  • The Hospital Anxiety and Depression Scale (HADS) was used for screening at baseline, two weeks, and two months post-abortion.

Main Results:

  • Pre-abortion, significant anxiety was noted in both spontaneous (13% severe) and induced (43.2% varying levels) abortion groups.
  • Mild to moderate depression was prevalent in 45.6% of spontaneous and 40.8% of induced abortion clients.
  • Anxiety levels decreased over time in spontaneous abortions but remained persistent in induced abortions; depression scores decreased for both.

Conclusions:

  • Anxiety and depression are common sequelae of early pregnancy loss.
  • Anxiety rates diminish over time following spontaneous abortion but persist after induced abortion.
  • Depression rates tend to decrease over time for both spontaneous and induced abortion types.