Multiplex plasma protein assays as a diagnostic tool for lung cancer
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View abstract on PubMed
Summary
This summary is machine-generated.This study identifies a panel of five plasma proteins that can help diagnose lung cancer (LC) noninvasively. Combining these with four additional proteins improves accuracy for advanced lung cancer and other cancers.
Area Of Science
- Oncology
- Biomarker Discovery
- Proteomics
Background
- Noninvasive diagnostic biomarkers for lung cancer (LC) are lacking, leading to delayed diagnosis.
- Early detection of LC is crucial for improving patient outcomes.
Purpose Of The Study
- To explore associations between plasma proteins and LC.
- To identify potential noninvasive diagnostic biomarkers for lung cancer.
Main Methods
- Analyzed 92 plasma proteins using the Olink Immuno-Onc-I panel in patients with suspected LC.
- Utilized generalized linear models (GLM) to assess protein expression associations with diagnoses, controlling for confounders.
Main Results
- A panel of five proteins (CD83, GZMA, GZMB, CD8A, MMP12) showed diagnostic performance for primary LC versus no cancer (NC).
- Adding four proteins (GAL9, PDCD1, CD4, HO1) enhanced diagnostic performance for advanced LC and other cancers.
Conclusions
- Specific plasma protein profiles show potential for distinguishing LC patients from NC.
- These proteins could serve as predictive biomarkers for early-stage LC detection and development of diagnostic tools.
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