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EQ-5D Based Utility Values for Adults with Chronic Obstructive Pulmonary Disease: A Systematic Review, Meta-Analysis,

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Summary

Recent studies show improved health utility values in chronic obstructive pulmonary disease (COPD) patients. However, significant heterogeneity necessitates careful use of these values in economic models.

Keywords:
Chronic obstructive pulmonary diseaseEQ-5Dheterogeneitymeta-analysisquality of lifeutility

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Area of Science:

  • Health Economics
  • Pulmonology
  • Quality of Life Research

Background:

  • Chronic obstructive pulmonary disease (COPD) significantly impacts health-related quality of life (QoL).
  • Utility values are crucial for cost-utility models in health economic evaluations and policy decisions.
  • Previous meta-analyses, like Moayeri et al. (2016), established baseline utility values for COPD.

Purpose of the Study:

  • To investigate changes in mean utility values for COPD in recent literature (2015-2024).
  • To explore heterogeneity in utility values across various clinical and study characteristics.
  • To update and refine utility estimates for economic modeling in COPD.

Main Methods:

  • Systematic literature searches were conducted in MEDLINE and Embase from July 2015 to May 2024.
  • A random-effects meta-analysis of EQ-5D utility values was performed, addressing inter-study heterogeneity.
  • Subgroup analyses and meta-regressions were used to identify moderators of utility values.

Main Results:

  • The pooled mean utility value from 43 recent studies was 0.761 (95% CI: 0.726-0.795), an increase from the 0.673 reported previously.
  • Significant heterogeneity was observed, indicating that a general utility value should be used cautiously.
  • Method of elicitation, disease stage, and region were identified as significant moderators of utility values.

Conclusions:

  • Updated meta-analysed utility values for COPD show improvement, potentially due to advancements in care.
  • Significant heterogeneity underscores the importance of using context-specific utility data in cost-utility analyses.
  • The findings support the use of meta-analysed utilities that reflect specific patient populations and study contexts, highlighting EQ-5D-5L's precision over EQ-5D-3L.