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Glial cells in the mammalian olfactory bulb
Dan Zhao1, Meigeng Hu1, Shaolin Liu1
1Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, Department of Biomedical Sciences, University of Georgia College of Veterinary Medicine, Athens, GA, United States.
Frontiers in Cellular Neuroscience
|July 31, 2024
Summary
Glial cells, including astrocytes and microglia, are crucial for the mammalian olfactory bulb
Area of Science:
- Neuroscience
- Cell Biology
Background:
- The mammalian olfactory bulb (OB) is key for odor processing.
- Research historically emphasized neurons, neglecting glial cell roles.
Purpose of the Study:
- To review the diverse functions of glial cells in the mammalian OB.
- To highlight their roles in neural health, disease, and regeneration.
Main Methods:
- Comprehensive literature review of glial cell functions in the OB.
- Focus on astrocytes, microglia, oligodendrocytes, olfactory ensheathing cells, and radial glia.
Main Results:
- Glial cells significantly influence synaptic modulation, neuronal survival, immune defense, and axonal guidance.
- Specific glial subtypes have unique contributions to OB functionality.
Conclusions:
- Glial cells are pivotal for olfactory system complexity and function.
- Understanding glial roles offers therapeutic potential for neuroregeneration and neurodegenerative diseases.
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