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[Peripheral sensitivity to insulin in aged subjects].

H Gin, G Manciet, E Brottier

    Diabete & Metabolisme
    |October 1, 1985
    PubMed
    Summary
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    Aging appears to decrease insulin sensitivity, as elderly individuals require less glucose to maintain stable insulin levels compared to younger adults. This suggests an apparent insulin resistance with aging.

    Area of Science:

    • Gerontology
    • Metabolic Research
    • Endocrinology

    Background:

    • Insulin resistance is a significant metabolic risk factor.
    • Aging is associated with various physiological changes.
    • Understanding age-related metabolic shifts is crucial for health management.

    Purpose of the Study:

    • To investigate the impact of aging on insulin sensitivity.
    • To compare insulin sensitivity between young and elderly individuals.

    Main Methods:

    • Utilized a two-hour hyperinsulinemic euglycemic clamp.
    • Employed an artificial pancreas (Biostator GCIIS Miles) for precise control.
    • Studied healthy young (mean age 22) and elderly (mean age 72) participants.

    Main Results:

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    • Both groups achieved stable hyperinsulinemic levels (approx. 90-93 uu/ml).
    • Elderly patients required significantly less glucose (5.5 mg/kg/min) than young patients (8.08 mg/kg/min) to maintain euglycemia.
    • Insulin metabolic clearance was not significantly altered by aging.

    Conclusions:

    • Despite similar insulin levels, elderly individuals exhibit reduced glucose uptake.
    • This indicates an apparent insulin resistance associated with the aging process.
    • Metabolic clearance of insulin remains unaffected, suggesting a post-receptor defect in aging.