Enhancing the Inhibition of Corneal Neovascularization Efficacy by Self-Assembled into Supramolecular Hydrogel of Anti-Angiogenic Peptide
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The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye
Published on: August 16, 2014
Guojuan Pu1,2, Zhen Liang1,2, Jieran Shi2
1Henan Eye Hospital, Henan Eye Institute, Henan Provincial People's Hospital, Zhengzhou, 450003, People's Republic of China.
Background:
Corneal neovascularization (CNV) is a common eye disease that leads to blindness. New treatment strategies are urgently needed due to the limitations of current treatment methods.
Methods:
We report the synthesis of peptide Nap-FFEEPCAIWF ( ) via chemical conjugation of Nap-FFEE ( ) to antiangiogenic peptide PCAIWF (. self-assembled into a hydrogel ( ) composed of nanofibers, which enhanced the antiangiogenic function of the epitope.
Results:
We developed a novel peptide with an amphiphilic framework, , which could self-assemble into a supramolecular hydrogel with a well-ordered nanofiber structure. The nanofibers exhibited good biocompatibility with corneal epithelial cells, presenting a promising strategy to enhance the efficacy of free peptide-based drugs in the treatment of ocular vascular diseases, such as CNV and other angiogenesis-related diseases.
Conclusion:
Nap-FFEEPCAIWF nanofibers provide an alternative approach to enhancing the therapeutic efficiency of free peptide-based drugs against ocular vascular diseases.
