Related Experiment Video
Updated: Jun 18, 2025
Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection
Published on: November 22, 2013
Legionella maceachernii pneumonia: a case report and literature review
Gaofeng Pan1,2,3, Maoying Fu1, Huihui Ni1
1Department of Infectious Diseases, The First People's Hospital of Kunshan, Kunshan, Jiangsu, China.
Background:
Legionella maceachernii pneumonia is a severe respiratory infection with low incidence but high mortality. However, the optimal treatment for this disease remains unclear. We report a case of successful treatment of Legionella maceachernii pneumonia, which is the first report of such a case in China.
Case Presentation:
An 87-year-old man with concomitant chronic obstructive pulmonary disease, liver cirrhosis, and history of left nephrectomy was diagnosed with Legionella maceachernii pneumonia using Dano-seq pathogen metagenomic testing. After two weeks of treatment with cefoperazone/sulbactam combined with quinolone antibiotics, the patient showed improvement and was discharged. The patient continued to take oral quinolone antibiotics for one week after discharge and recovered during outpatient follow-up.
Conclusions:
Dano-seq pathogen metagenomic testing can rapidly diagnose Legionella maceachernii pneumonia, and taking quinolone antibiotics is an effective treatment.
Insights
Legionella maceachernii pneumonia, a severe infection, was successfully treated in an elderly patient in China. Rapid Dano-seq diagnosis and quinolone antibiotics proved effective for this rare condition.
Area of Science:
- Infectious Diseases
- Microbiology
- Respiratory Medicine
Background:
- Legionella maceachernii pneumonia is a rare but severe respiratory infection with high mortality.
- Optimal treatment strategies for Legionella maceachernii pneumonia are not well-established.
- This case represents the first reported successful treatment of Legionella maceachernii pneumonia in China.
Observation:
- An 87-year-old male patient with multiple comorbidities was diagnosed with Legionella maceachernii pneumonia.
- Diagnosis was confirmed using Dano-seq pathogen metagenomic testing.
- The patient received a combination of cefoperazone/sulbactam and quinolone antibiotics.
Findings:
- Dano-seq pathogen metagenomic testing offers rapid and accurate diagnosis of Legionella maceachernii pneumonia.
- Combination therapy with cefoperazone/sulbactam and quinolone antibiotics led to successful patient recovery.
- Oral quinolone antibiotics were effective for post-discharge treatment.
Implications:
- This case highlights the utility of Dano-seq in diagnosing rare bacterial pneumonias.
- Quinolone antibiotics are confirmed as an effective treatment option for Legionella maceachernii pneumonia.
- Early diagnosis and appropriate antibiotic therapy are crucial for improving outcomes in severe Legionella infections.
Related Concept Videos
01:30Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
01:30Pneumonia III: Complications and Assessment
01:30Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
01:29Pneumonia II: Pathophysiology