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New Flavan Derivatives from the Leaves and Stems of Cassia Nodosa
Qiong-Hui Sun1,2, Li-Mei Yu1, Wen Yan1
1School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650050, P. R. China.
Abstract:
Three new flavan derivatives including two methylene-linked flavan-3-ol dimers, bis(8-epiafzelechinyl)methane (1), and 8,8-(epiafzelechin-afzelechin)methane (2), a flavan-3-ol monomer, (-)-3-O-acetyl-epiafzelechin (3) and four known related compounds (4-7) were isolated from the leaves and stems of Cassia nodosa. Their structures were elucidated by extensive spectroscopic analyses and CD data. The isolates were evaluated for their antioxidant, α-glucosidase inhibitory, cytotoxic and neuroinflammatory activities, and compound 3 exhibited remarkable radical scavenging activities in both the DPPH and ABTS models with IC50 values of 2.65±1.25, and 4.78±0.91 μg/mL, respectively.
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