Related Experiment Video
Updated: Jun 18, 2025
09:04
Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
Published on: February 20, 2018
12.5K
Intrinsic Capacity and Its Biological Basis: A Scoping Review
M B Beyene1, R Visvanathan, A T Amare
1Azmeraw T. Amare, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia, Tel: +61 8 83137438,
The Journal of Frailty & Aging
|July 31, 2024
Summary
Healthy aging, defined by intrinsic capacity (IC), is linked to various health factors. Further research is needed on the genetic and environmental influences on IC, utilizing biobank data.
Area of Science:
- Gerontology and Public Health
- Genetics and Aging Research
Background:
- The World Health Organization (WHO) introduced intrinsic capacity (IC) in 2015 as a measure of healthy aging based on functional capacity.
- This scoping review examines the development, validation, and associations of IC index scores, alongside its biological underpinnings.
Purpose of the Study:
- To summarize evidence on intrinsic capacity (IC) development and validation.
- To explore associations between IC and health-related factors.
- To identify research gaps in the genetic mechanisms and gene-environment interactions of IC.
Main Methods:
- A comprehensive literature search was performed across six major scientific databases.
- Keywords related to intrinsic capacity (IC) were used to identify relevant studies.
Main Results:
- Eighty-four articles were included, with 38 using a 5-domain approach for IC operationalization.
- Intrinsic capacity showed significant associations with socio-demographic factors, lifestyle, functional status, and health outcomes.
- While composite IC biological basis studies are limited, specific IC domains suggest substantial heritability (20-85%) and identified genetic variants, but gene-environment interaction data is absent.
Conclusions:
- Inconsistent standardized IC measurement tools were noted, yet IC indices demonstrated good construct and predictive validity.
- Significant gaps exist in understanding the genetic and gene-to-environment interactions influencing IC.
- Leveraging large biobank datasets is recommended for future research on IC's genetic basis.
More Related Videos
08:37Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
Published on: November 15, 2024
314
09:24A Rapidly Incremented Tethered-Swimming Maximal Protocol for Cardiorespiratory Assessment of Swimmers
Published on: January 28, 2020
8.8K
Related Concept Videos
01:24Respiratory Capacities
781
Respiratory capacities are crucial indicators of lung function, representing the maximum amount of air an individual's respiratory system can handle during various breathing phases.
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
781
01:47Lung Capacity
50.0K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
50.0K
01:22Respiratory Volumes and Capacities
1.8K
The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...
1.8K
01:30Biological Influences on Intelligence
84
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
84
01:29Pathophysiology of Cardiac Performance
624
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
624
01:30Introduction to Biological Bases of Psychology
3.2K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
The nervous system, the cornerstone of...
3.2K