Insight Into Severe Neonatal COVID-19 Gained Through Whole Exome Sequencing of Twin Neonates
Jennie Godwin1, John Daniel, Susana Chavez-Bueno
1From the Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Missouri.
The Pediatric Infectious Disease Journal
|July 31, 2024
Abstract:
The genetic basis of neonatal COVID-19 infection, which exhibits a range of severity, has not been investigated. We identified both shared and unique genetic variants involved in antiviral immune responses through whole exome sequencing of an infant who developed severe COVID-19 pneumonia and multisystem inflammatory syndrome and the twin brother also positive for severe acute respiratory syndrome-coronavirus-2, but with only moderate respiratory symptoms.
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