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Risk Factors of Cardiac Complications in Pregnant Women with Hypertrophic Cardiomyopathy

T T Huang1, S H Feng, J H Lin

  • 1Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, China.

Nigerian Journal of Clinical Practice
|July 31, 2024
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) in pregnancy poses risks like maternal death and heart failure. Obstructive HCM, NYHA class II, and prior syncope predict these serious cardiac complications.

Area of Science:

  • Cardiology
  • Maternal-Fetal Medicine
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a prevalent inherited cardiac condition affecting pregnant individuals.
  • Understanding risk factors is crucial for improving maternal and fetal outcomes in pregnancies complicated by HCM.

Purpose of the Study:

  • To identify predictive risk factors for cardiac complications in pregnant women diagnosed with hypertrophic cardiomyopathy.

Main Methods:

  • Retrospective review of 100 patients with HCM delivering between 2000-2022.
  • Logistic regression analysis to determine independent risk factors for cardiac complications.

Main Results:

  • Cardiac complications included maternal death (2%), heart failure (7%), and ventricular tachyarrhythmia (1%).
  • Key predictors identified were obstructive HCM (P=0.036), NYHA class ≥II (P=0.022), and a history of syncope (P=0.037).
  • Complications predominantly occurred in the third trimester and postpartum period.

Conclusions:

  • HCM significantly elevates risks for maternal mortality, heart failure, and arrhythmias during pregnancy.
  • Enhanced risk assessment and tailored pregnancy management are essential.
  • Early identification of risk factors can mitigate maternal mortality and cardiac complications.
Abstract

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