Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gossypol-hypokalaemia interrelationships.

S Z Qian

    International Journal of Andrology
    |August 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Gossypol, used as a male contraceptive, can cause hypokalaemic paralysis due to renal potassium loss. Low dietary potassium intake significantly increases the risk of developing this condition, even after treatment cessation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of tripchlorolide on the epididymides and testes of rats.

    Asian journal of andrology·2001
    Same author

    Hormonal deficiency in elderly males.

    International journal of andrology·2000
    Same author

    A randomized multicenter study comparing the efficacy and bleeding pattern of a single-rod (Implanon) and a six-capsule (Norplant) hormonal contraceptive implant.

    Contraception·1999
    Same author

    A long-term study of the efficacy and acceptability of a single-rod hormonal contraceptive implant (Implanon) in healthy women in China.

    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception·1999
    Same author

    Effect of intrauterine injection of chlorpromazin on implantation in the rat.

    Contraception·1999
    Same author

    Subcapsular intratesticular assay: a preliminary screening method for putative male antifertility drugs.

    International journal of andrology·1995

    Area of Science:

    • Endocrinology
    • Nephrology
    • Pharmacology

    Background:

    • Gossypol is investigated as a male contraceptive agent.
    • Hypokalaemia and hypokalaemic paralysis are potential side effects observed in users.
    • Renal potassium loss is identified as the primary cause of these adverse effects.

    Purpose of the Study:

    • To investigate the incidence and contributing factors of gossypol-induced hypokalaemia.
    • To explore the relationship between dietary potassium and the risk of hypokalaemia.
    • To understand the underlying mechanisms of gossypol's effect on potassium levels.

    Main Methods:

    • Clinical observation of volunteers using gossypol.
    • Analysis of serum potassium levels in gossypol users and controls.

    Related Experiment Videos

  • Animal studies using rats fed varying potassium diets.
  • Investigation of regional differences in hypokalaemia incidence.

    • Main Results:

    • Approximately 1% of gossypol users experienced hypokalaemic paralysis, with more cases of simple hypokalaemia.
    • Lower dietary potassium intake correlated with higher incidence of hypokalaemic paralysis.
    • Gossypol reduced intracellular magnesium and potassium in rat skeletal muscle on a low-potassium diet.
    • Recurrent hypokalaemia occurred in some individuals months to years after discontinuing gossypol.

    Conclusions:

    • Dietary potassium deficiency is a significant contributing factor to gossypol-induced hypokalaemia.
    • Gossypol's adverse effects on potassium levels may involve renal mechanisms and ion transport.
    • Further research into gossypol's impact on electrolyte balance and potential long-term effects is warranted.