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Cocaine: an overview of current issues.

J Grabowski, S I Dworkin

    The International Journal of the Addictions
    |June 1, 1985
    PubMed
    Summary

    This review critically examines cocaine use, covering prevalence, patterns, and hazards. It emphasizes developing integrated models for drug abuse and informed public policy for cocaine and stimulant control.

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    The effects of acutely administered cocaine on responding maintained by a progressive-ratio schedule of food presentation.

    Behavioural pharmacology·2003

    Area of Science:

    • Neuroscience
    • Public Health
    • Pharmacology

    Background:

    • Cocaine use has significant scientific, public health, and political implications.
    • Numerous reviews exist, necessitating a focused critical overview.

    Purpose of the Study:

    • To provide a critical overview of cocaine use and prevalence.
    • To address current issues related to cocaine use, including patterns, hazards, and treatment.
    • To suggest future directions for policy and research.

    Main Methods:

    • Review of laboratory, epidemiological, and clinical data.
    • Analysis of patterns of use, dose, tolerance, sensitization, routes of administration, and hazards.
    • Discussion of treatment aspects.

    Main Results:

    • Identified patterns of use, dose-response relationships, tolerance, and sensitization.
    • Detailed the various routes of administration and associated hazards.
    • Addressed current treatment strategies and their limitations.

    Conclusions:

    • A comprehensive model of drug abuse requires integrating pharmacological, neurochemical, behavioral, and environmental factors.
    • Future research and public policy should be informed by historical perspective and current concerns regarding cocaine and other stimulants.

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