Related Experiment Video
Updated: Jun 18, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Diagnostic Performance of Stool-based Testing for Colorectal Lesions Among Average-risk Individuals: A Real-world
Catherine Cheney1, Alice Parish2, Donna Niedzwiecki2
1Department of Medicine, Duke University Medical Center.
Objective:
We assessed the real-world performance of stool-based tests (SBTs) for colorectal cancer screening.
Materials And Methods:
Retrospective review of average-risk individuals with positive SBT for advanced neoplasia (adenocarcinoma, advanced adenoma, and/or advanced serrated lesions) detection at follow-up colonoscopy.
Results:
There was no statistical difference in the detection of advanced neoplasia ( P = 0.16) between SBTs [30.7% for multitargeted stool DNA (mt-sDNA) vs 22.8% for fecal immunochemical test]. However, there was a significant difference in the detection of advanced serrated lesions (11.3% for mt-sDNA vs 1.8% for fecal immunochemical test, P < 0.001).
Conclusion:
There was no difference between SBTs for advanced neoplasia detection, though mt-sDNA detected significantly more advanced serrated lesions.
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