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Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 21, 2026

PuraMatrix Encapsulation of Cancer Cells

PuraMatrix Encapsulation of Cancer Cells

Published on: December 18, 2009

Introducing the PLOS collection on rare cancer.

Mitesh J Borad^1,2,3

¹Division of Hematology/Oncology, Mayo Clinic, Scottsdale, Arizona, United States of America.

|July 31, 2024

Summary

Rare cancers, though common collectively, lack research and guidelines. This collection highlights diverse studies, from basic science to drug development, addressing this gap in rare cancer research.

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Rare Event Detection Using Error-corrected DNA and RNA Sequencing

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Published on: November 5, 2019

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Last Updated: May 21, 2026

PuraMatrix Encapsulation of Cancer Cells

PuraMatrix Encapsulation of Cancer Cells

Published on: December 18, 2009

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Area of Science:

Oncology
Rare Diseases
Clinical Research

Background:

Rare cancers are defined by low incidence rates.
They represent up to 24% of all cancer diagnoses.
Lack of evidence hinders uniform standards of care and clinical guidelines for rare cancers.

Purpose of the Study:

To introduce the PLOS Rare Cancer Collection.
To provide an overview of research endeavors in rare cancers.
To highlight contributions within the collection.

Main Methods:

The collection encompasses a broad range of research.
Studies include basic biological evaluations.
Research extends to therapeutic drug development.

Main Results:

The collection aggregates diverse research on rare cancers.
It showcases progress from basic science to clinical applications.
Included articles contribute significantly to the field.

Conclusions:

The PLOS Rare Cancer Collection addresses the understudied nature of rare cancers.
It fosters a multidisciplinary approach to rare cancer research.
The collection aims to improve clinical and societal impact for rare cancer patients.