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Updated: Aug 14, 2026
Mimicking and Measuring Occlusal Erosive Tooth Wear with the "Rub&Roll" and Non-contact Profilometry
Published on: February 2, 2018
Experimental toothpastes containing β-TCP nanoparticles functionalized with fluoride and tin to prevent Erosive Tooth
Guilherme Stangler Weiss1, Flávia Rodrigues Oliveira Silva2, Raíssa Manoel Garcia1
1Department of Restorative Dentistry, University of São Paulo (USP), School of Dentistry, Av. Prof Lineu Prestes 2227, São Paulo, SP, 05508-000, Brazil.
Objectives:
The present study aimed to synthesize toothpastes containing Beta- TriCalcium Phosphate (β-TCP) nanoparticles, functionalized with fluoride and tin, and test their ability to reduce erosive tooth wear (ETW).
Methods:
Toothpastes were synthesized with the following active ingredients: 1100 ppm of fluoride (as sodium fluoride, F-), 3500 ppm of tin (as stannous chloride, Sn2+), and 800 ppm of β-TCP (Sizes a - 20 nm; and b - 100 nm). Enamel specimens were randomly assigned into the following groups (n = 10): 1. Commercial toothpaste; 2. Placebo; 3 F-; 4. F- + β-TCPa; 5. F- + β-TCPb; 6. F- + Sn2+; 7. F- + Sn2+ + β-TCPa and 8. F- + Sn2+ + β-TCPb. Specimens were subjected to erosion-abrasion cycling. Surface loss (in µm) was measured by optical profilometry. Toothpastes pH and available F- were also assessed.
Results:
Brushing with placebo toothpaste resulted in higher surface loss than brushing with F- (p = 0.005) and F- + β-TCPb (p = 0.007); however, there was no difference between F- and F- + β-TCPb (p = 1.00). Commercial toothpaste showed no difference from Placebo (p = 0.279). The groups F-, F- + β-TCPa, F- + β-TCPb, F- + Sn2+, F- + Sn2+ + β-TCPa and F- + Sn2+ + β-TCPb were not different from the commercial toothpaste (p > 0.05). Overall, the addition of β-TCP reduced the amount of available fluoride in the experimental toothpastes. The pH of toothpastes ranged from 4.97 to 6.49.
Conclusions:
Although toothpaste containing β-TCP nanoparticles protected enamel against dental erosion-abrasion, this effect was not superior to the standard fluoride toothpaste (commercial). In addition, the functionalization of β-TCP nanoparticles with fluoride and tin did not enhance their protective effect.
Clinical Significance:
Although β-TCP nanoparticles have some potential to control Erosive Tooth Wear, their incorporation into an experimental toothpaste appears to have a protective effect that is similar to a commercial fluoride toothpaste.
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