Social vulnerability and survival in 112 000 adolescents and young adults with cancer: a population-based study
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View abstract on PubMed
Summary
This summary is machine-generated.Neighborhood social vulnerability significantly impacts cancer survival for adolescents and young adults (AYAs). Higher vulnerability is linked to decreased survival rates, highlighting the need for targeted interventions to address health disparities.
Area Of Science
- Oncology
- Public Health
- Social Epidemiology
Background
- Neighborhood factors influence cancer outcomes, yet research often overlooks adolescents and young adults.
- Social vulnerability, encompassing various socioeconomic risks, is a key area of interest in health disparities.
Purpose Of The Study
- To investigate the association between neighborhood-level social vulnerability and cancer survival in adolescents and young adults (AYAs).
- To quantify the impact of social vulnerability on all-cause mortality in AYAs diagnosed with cancer.
Main Methods
- Utilized population-based data from the Texas Cancer Registry, including 112,142 AYAs (age 15-39).
- Assessed neighborhood social vulnerability using a composite measure of 14 census tract-level social risk factors.
- Estimated 1-, 5-, and 10-year overall survival rates across quintiles of social vulnerability.
- Employed Cox proportional hazards models to determine the association between social vulnerability and all-cause mortality.
Main Results
- Cancer survival rates decreased progressively with increasing levels of social vulnerability.
- Five-year survival was notably lower in the most vulnerable quintile (74.0%) compared to the least vulnerable quintile (86.5%).
- Social vulnerability was significantly associated with increased all-cause mortality in adjusted models (aHR = 1.55 for highest vs. lowest quintile).
Conclusions
- Neighborhood social vulnerability is a critical determinant of cancer survival for adolescents and young adults.
- Addressing neighborhood disparities is essential for achieving equitable cancer outcomes in AYAs.
- Interventions targeting social determinants of health are necessary to improve survival rates in vulnerable populations.
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