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Updated: Jun 18, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Update on Preeclampsia and Hypertensive Disorders of Pregnancy
Emily A Rosenberg1, Ellen W Seely2
1Division of Endocrinology, Diabetes, and Metabolic Diseases, Medical University of South Carolina, 96 Jonathan Lucas Street, CSB 822, Charleston, SC 29425, USA.
Abstract:
There have been recent advances in the prevention, diagnosis, and management of hypertensive disorders of pregnancy which complicate approximately 16% of pregnancies in the United States. Initiation of low-dose aspirin by 16 weeks' gestation reduces preeclampsia in high-risk women. The Food and Drug Administration approved the use of the soluble fms-like tyrosine kinase 1/placental growth factor ratio for the short-term prediction of preeclampsia. Pregnancy outcomes are improved in women with chronic hypertension when antihypertensives are initiated at a threshold blood pressure of 140/90 mm Hg. Women with prior preeclampsia have increased cardiovascular disease risk and should receive risk reduction counseling.
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