Related Experiment Video
Updated: Jun 18, 2025
06:27
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
710
Reproductive Considerations in the Transgender and Gender Diverse Population: A Review
Michele B Glodowski1, Carlos M Parra2, Madeline K Xin3
1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Langone Health, 111 Broadway, 2nd Floor, New York, NY 10006, USA.
Endocrinology and Metabolism Clinics of North America
|July 31, 2024
Summary
Gender-affirming treatments can impact fertility in transgender and gender diverse individuals. Fertility preservation options like oocyte, embryo, and sperm cryopreservation should be discussed before treatment begins.
Area of Science:
- Reproductive Endocrinology
- Gender-Affirming Care
- Medical Ethics
Background:
- Transgender and gender diverse (TGD) individuals often require medically necessary gender-affirming treatments.
- These treatments can negatively affect reproductive potential and fertility.
- Fertility counseling is crucial for TGD individuals of reproductive age.
Purpose of the Study:
- To review current fertility preservation options for transgender and gender diverse individuals.
- To highlight the impact of gender-affirming treatments on reproductive health.
- To identify knowledge gaps and areas for future research in TGD reproductive healthcare.
Main Methods:
- Literature review of reproductive technologies and outcomes for TGD individuals.
- Analysis of current guidelines and recommendations for fertility preservation.
- Synthesis of data on cryopreservation techniques for gametes and reproductive tissues.
Main Results:
- Post-pubertal TGD individuals can utilize mature oocyte, embryo, and sperm cryopreservation.
- Prepubertal TGD individuals may consider ovarian tissue cryopreservation; testicular tissue cryopreservation is experimental.
- Despite technological advances, significant knowledge gaps persist in TGD reproductive health.
Conclusions:
- Comprehensive fertility counseling is essential for all TGD individuals considering gender-affirming care.
- Established cryopreservation methods offer viable fertility preservation options for many TGD individuals.
- Further research is needed to advance reproductive healthcare options for the TGD population.
Related Concept Videos
01:31Overview of the Reproductive System
1.1K
The reproductive system generates offspring, ensuring the survival of the species. In humans, the reproductive system is complex and involves a variety of organs and hormones that work together to ensure successful reproduction.
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
1.1K
01:24Gonadal and Placental Hormones
1.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.4K
01:41Spermatogenesis
102.3K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.3K
01:23Infertility in Males
256
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
256
01:24Tissue Transplantation
352
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
352
01:23Criticisms of the Evolutionary Perspective
92
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
Evolutionary psychology provides one explanation for these findings, suggesting...
92