Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

613
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
613
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

715
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
715
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

143
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
143
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

524
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
524
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
What are Lipids?01:38

What are Lipids?

197.0K
Overview
197.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pan-tumor validation of FoundationOne<sup>®</sup>CDx as a companion diagnostic for <i>RET</i> fusions as a predictor of response to selpercatinib.

Frontiers in oncology·2026
Same author

Evaluation of patients' perception of pharmacist's role within a post-ICU recovery clinic: the Critical Illness Recovery Center (E-PICS-Rx).

The International journal of pharmacy practice·2026
Same author

Understanding stressors in combination: a continued challenge for human performance.

Experimental physiology·2026
Same author

The 2025 AACE Dyslipidemia Guidelines - Cost concerns over evidence and missing the target?

Journal of clinical lipidology·2026
Same author

Implementation pathways of a health services delivery redesign model to improve maternal and newborn outcomes in Kenya.

BMJ global health·2026
Same author

Prevention and treatment of hypertriglyceridemia-mediated acute pancreatitis: A narrative review.

European journal of internal medicine·2025
Same journal

Care Transitions Continue to Evolve.

The Medical clinics of North America·2026
Same journal

Navigating the Gaps: A Comprehensive Overview of Care Transitions Across the Continuum.

The Medical clinics of North America·2026
Same journal

Care Transitions and Value-Based Payment Models in the United States.

The Medical clinics of North America·2026
Same journal

Technology and Innovation in Care Transitions: Imagining the Future of Postdischarge Care.

The Medical clinics of North America·2026
Same journal

Primary Care, Specialists, and Hospitals: Bridging the Gaps in Communication and Coordination.

The Medical clinics of North America·2026
Same journal

Social Determinants of Health: Unique Considerations in Transitions of Care.

The Medical clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.6K

Therapy for Hyperlipidemia.

Jennifer Wright1, Savitha Subramanian2

  • 1Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.

The Medical Clinics of North America
|July 31, 2024
PubMed
Summary
This summary is machine-generated.

Recent advances improve atherosclerotic cardiovascular disease (ASCVD) risk assessment using lipid panels and coronary artery calcium imaging. High-risk patients benefit from statins plus add-on therapies like PCSK9 inhibitors for reduced cardiovascular risk.

Keywords:
ASCVDBempedoic acidCoronary artery calciumEzetimibeHypertriglyceridemiaLipoprotein (a)PCSK9 inhibitorsStatins

More Related Videos

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

1.9K
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.1K

Related Experiment Videos

Last Updated: Jun 18, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.6K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

1.9K
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.1K

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Pharmacology

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality globally.
  • Risk stratification and treatment strategies have evolved significantly over the past decade.
  • Current guidelines emphasize personalized risk assessment and tailored therapeutic interventions.

Purpose of the Study:

  • To review recent advancements in ASCVD risk stratification and treatment.
  • To highlight the role of lipid panels and coronary artery calcium (CAC) imaging in risk estimation.
  • To discuss the current evidence for pharmacologic interventions in ASCVD risk reduction.

Main Methods:

  • Review of recent clinical guidelines and landmark cardiovascular outcomes trials.
  • Analysis of data regarding the efficacy and safety of lipid-lowering agents.
  • Evaluation of the utility of CAC scoring in clinical practice.

Main Results:

  • Lipid panels are foundational, with CAC imaging increasingly utilized for individual risk assessment.
  • Statins are first-line therapy; ezetimibe, PCSK9 inhibitors, and bempedoic acid offer additional risk reduction in high-risk individuals.
  • Triglyceride-lowering medications lack proven ASCVD risk reduction, except for icosapent ethyl in specific populations.

Conclusions:

  • Personalized ASCVD risk assessment integrates traditional markers with advanced imaging.
  • A multi-drug approach, guided by risk assessment, is crucial for optimal cardiovascular risk reduction.
  • Therapeutic decisions should be evidence-based, considering the specific role of each agent in reducing cardiovascular events.