Gastric Leiomyosarcoma Completely Resected by Endoscopic Submucosal Dissection after a Precise Preoperative Diagnosis

Area of Science:

• Gastroenterology
• Surgical Oncology

Background:

• Gastric leiomyosarcoma (LMS) is a rare malignancy.
• Surgical resection is the primary treatment modality for gastric LMS.
• Limited data exists on minimally invasive endoscopic treatments for gastric LMS.

Purpose of the Study:

• To report a rare case of gastric LMS treated with endoscopic submucosal dissection (ESD).
• To evaluate the efficacy and safety of ESD for gastric LMS.
• To assess long-term outcomes after ESD for gastric LMS.

Main Methods:

• Preoperative biopsy and endoscopic ultrasonography (EUS) for precise diagnosis and staging.
• Endoscopic submucosal dissection (ESD) for complete tumor resection.
• Long-term follow-up for recurrence.

Main Results:

• A 68-year-old woman with gastric LMS confined to the submucosa underwent ESD.
• Complete tumor resection was achieved.
• No recurrence was observed during 2.5 years of follow-up.

Conclusions:

• ESD is a potentially effective and safe treatment option for selected gastric LMS cases.
• Precise preoperative diagnosis using EUS is crucial for successful ESD.
• Gastric LMS treated with ESD can have favorable long-term outcomes.