Fibrinogen-to-Albumin Ratio in Patients with Acute Heart Failure

Area of Science:

• Cardiology
• Biomarkers
• Acute Heart Failure

Background:

• The fibrinogen-to-albumin ratio (FAR) is an emerging biomarker.
• Its role in acute heart failure (AHF) requires further investigation.

Purpose of the Study:

• To evaluate the association between FAR and clinical characteristics in AHF patients.
• To assess the prognostic value of FAR for mortality and heart failure events in AHF.

Main Methods:

• Analysis of 1,402 hospitalized AHF patients.
• Calculation of FAR (plasma fibrinogen/serum albumin × 1,000).
• Multivariate logistic regression and Cox proportional hazards models were used.

Main Results:

• High FAR was associated with inflammation (C-reactive protein), ischemic heart disease, and diabetes mellitus.
• Elevated FAR predicted poorer 730-day all-cause mortality in the overall AHF cohort.
• Low FAR was an independent predictor of increased 730-day mortality and heart failure events specifically in the low-albumin subgroup.

Conclusions:

• FAR is associated with inflammation and comorbidities in AHF.
• High FAR indicates adverse prognosis in the general AHF population.
• Low FAR signifies poor prognosis in AHF patients with low serum albumin.