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Biologic therapy for ulcerative colitis associated with immune thrombocytopenia

Manabu Nagayama1,2, Yohei Funayama1, Osamu Taniguchi1

  • 1Division of Gastroenterology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

Clinical Journal of Gastroenterology
|July 31, 2024
PubMed

Ulcerative colitis (UC), a subtype of inflammatory bowel disease, occasionally manifests with extraintestinal manifestations. We present a 51-year-old male with refractory UC and immune thrombocytopenia (ITP) resistant to conventional treatments. The introduction of biologics, ustekinumab or adalimumab, resulted in clinical remission of colitis and improvements in platelet count. This case underscores the efficacy of biologics in managing refractory UC associated with ITP, emphasizing their potential to control intestinal inflammation and address concurrent thrombocytopenia, potentially avoiding surgical intervention.

Keywords:
Bacterial mimicryBiologicsExtraintestinal manifestationsImmune thrombocytopeniaUlcerative colitis

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