Multidisciplinary lifestyle interventions for neurological disorders during the Silent phase (MINDS) study: a...

Area of Science:

• Neurology
• Preventive Medicine
• Biomarker Discovery

Background:

• Neurological disorders pose significant health and economic burdens.
• Early detection and intervention are crucial for managing neurological conditions.
• Multidisciplinary lifestyle interventions (MLI) show promise in mitigating neurological disorder risk.

Purpose of the Study:

• To evaluate the impact of MLI on the progression of neurological disorders.
• To identify multi-omic biomarkers for early-stage neurological diseases.
• To assess MLI's effect on these identified biomarkers.

Main Methods:

• The Multidisciplinary lifestyle Interventions for Neurological Disorders during the Silent phase (MINDS) protocol is a randomized controlled trial.
• Participants (≥50 years) at elevated risk for stroke, epilepsy, Parkinson's, or Alzheimer's are randomized to intervention or control groups.
• The intervention includes diet, yoga, music therapy, and cognitive training over 3 months, with 12-month follow-up including neuroimaging and multi-omic analyses.

Main Results:

• Primary outcomes focus on neurological disorder risk progression or clinical diagnosis.
• Secondary outcomes include self-reported health and multi-omic data.
• Data analysis will compare between-group and within-group longitudinal changes.

Conclusions:

• The MINDS trial will clarify MLI's efficacy in older adults at risk for neurological disorders.
• Biomarker data will validate MLI's impact on disease progression.
• This research aims to identify individuals who may benefit most from early MLI therapies.