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Frequency-dependent effects of 0.05% atropine eyedrops on myopia progression and peripheral defocus: a prospective

Yuanfang Yang1, Minsong Xue1, Jiangdong Hao1

  • 1Aier School of Ophthalmology, Central South University, Changsha, 410015, China.

Eye and Vision (London, England)
|July 31, 2024
PubMed

Insights

Low-dose atropine eyedrops slow myopia progression in children. Daily use is most effective, but even weekly use impacts peripheral refraction, with temporal retinal changes linked to slower progression.

Area of Science:

  • Ophthalmology
  • Pediatric Optometry
  • Myopia Control

Background:

  • 0.05% atropine eyedrops are effective in slowing myopia progression.
  • This study investigates peripheral refraction (PR) in myopic children using 0.05% atropine at varying frequencies.

Purpose of the Study:

  • To evaluate the impact of different 0.05% atropine eyedrop frequencies on peripheral refraction in children with myopia.
  • To understand the relationship between atropine frequency, myopia progression, and changes in peripheral refractive error.

Main Methods:

  • A one-year prospective study involving 138 myopic children randomly assigned to once daily (7/7), twice weekly (2/7), or once weekly (1/7) atropine treatment.
  • Measurements included spherical equivalent (SE), axial length (AL), and peripheral refraction (PR) using a Hartmann-Shack wavefront sensor.
  • Relative peripheral refraction (RPR) was calculated by subtracting central from peripheral measurements.

Main Results:

  • The once-weekly (1/7) group showed significantly greater SE increase and AL elongation compared to daily (7/7) and twice-weekly (2/7) groups.
  • The 1/7 group exhibited more myopic PR in the fovea and superior, inferior, and nasal retina, with less myopic RPR peripherally.
  • The 7/7 group showed a myopic RPR shift across the entire retina, while the 1/7 group had a hyperopic shift in the superior retina; temporal RPR myopic shift correlated with less myopia progression.

Conclusions:

  • Atropine inhibits myopia progression in a frequency-dependent manner, with daily use being most effective.
  • While daily atropine (7/7) slowed progression most, it induced more myopic shifts in RPR.
  • Relative peripheral refraction in the temporal retina is associated with myopia progression across all treatment groups.
Abstract

Keywords:
0.05% atropine eyedropsMedication complianceMyopia controlPeripheral defocus

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