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Updated: Jun 18, 2025

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
Published on: September 7, 2017
The role of ribosomal DNA methylation in embryonic development, aging and diseases
Fei Yang1,2, Xutong Guo1,2,3, Yiming Bao4,5,6
1National Genomics Data Center, China National Center for Bioinformation, Beijing, 100101, China.
Abstract:
The ribosomal DNA (rDNA) constitutes a remarkably conserved DNA sequence within species, located in the area of the nucleolus, and responsible for coding three major types of rRNAs (18S, 5.8S and 28S). While historical investigations into rDNA focused on its structure and coding capabilities, recent research has turned to explore its functional roles in various biological processes. In this review, we summarize the main findings of rDNA methylation with embryonic development, aging and diseases in multiple species, including epigenetic alterations, related biological processes and potential applications of rDNA methylation. We present an overview of current related research and identify gaps in this field.
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