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Updated: Jun 18, 2025

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein
Published on: May 30, 2015
α-Synuclein in speculative neuronal extracellular vesicles: A marker for Parkinson's disease risk?
1Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Abstract:
This opinion piece describes major limitations of using α-synuclein in speculative neuronally enriched for diagnosing or predicting Parkinson's disease risk from prodromal conditions such as REM behaviour disorder. It concludes that such an approach is unreliable and recommends that future researchers divert away to more widely accepted approaches such as seed amplification assays.
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