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Related Concept Videos

iChip01:24

iChip

107
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
107
Gut-Brain Axis01:22

Gut-Brain Axis

249
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
249

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Related Experiment Video

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Generation of a Human iPSC-Based Blood-Brain Barrier Chip
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Advances in gut-brain organ chips.

Yu Zhang1,2, Si-Ming Lu3,4,5, Jian-Jian Zhuang1,2

  • 1Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.

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Summary

Organ-on-a-chip technology offers a novel way to study the brain-gut axis, overcoming limitations of animal models for better disease research and drug development.

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Biotechnology

Background:

  • The brain-gut axis is crucial for health and disease, but animal models present challenges in studying its mechanisms.
  • Species differences and individual variations in animal models limit reproducibility and real-time sensory response analysis.

Purpose of the Study:

  • To review the history and current advancements in brain, gut, and gut-brain organ-on-a-chip systems.
  • To highlight the significance of these in vitro models for understanding pathophysiology and developing novel therapeutics.

Main Methods:

  • Review of existing literature on organ-on-a-chip technologies applied to brain-gut axis research.
  • Analysis of the capabilities of brain and gut chips for in vitro modeling.

Main Results:

  • Organ-on-a-chip platforms enable precise in vitro replication of brain and gut ecosystems.
  • These systems facilitate a detailed understanding of biological functions and physiological responses.

Conclusions:

  • Brain-gut-on-a-chip technologies represent a significant advancement for studying the brain-gut axis.
  • These models hold promise for personalized medicine, drug discovery, and overcoming limitations of traditional research methods.